New short strategy for the synthesis of the dibenz[b,f]oxepin scaffold.
نویسندگان
چکیده
In this report a short and efficient synthesis of the dibenz[b,f]oxepin framework through intramolecular SNAr and McMurry reactions is described. The diaryl ethers required for the McMurry reaction have been obtained in good yields under microwave-assisted conditions of the reaction of salicylaldehydes with fluorobenzaldehydes without catalysts. Application of an intramolecular McMurry reaction to the synthesized diarylethers using TiCl4/Zn in THF gave the target dibenzo[b,f]oxepin system in 53%-55% yields.
منابع مشابه
A New Dibenz[b, e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b, e]oxepin-6,11-dione, from a Marine-Derived Fungus, Beauveria bassiana TPU942
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عنوان ژورنال:
- Molecules
دوره 18 12 شماره
صفحات -
تاریخ انتشار 2013